Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14146858 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL8343815 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL20261700 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL7535395 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL30573752 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL1687895 | 0.95 | ALDH1A1 (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| Hydrochloric Acid SCHEMBL28969274 | 0.93 | ALDH1A1 (0.43) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL890725 | 0.91 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL8483813 | 0.89 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL11050599 | 0.89 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230302162-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2023-09-28 | — | — | US | disclosed |
| US-11583596-B2 | Radiolabeled Darapladib and analogs thereof and their use as imaging compounds | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2023-02-21 | — | — | US | disclosed |
| EP-3687980-B1 | RADIOLABELED DARAPLADIB, ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INST NAT SANTE RECH MED (FR) | 2022-01-19 | — | — | EP | disclosed |
| US-20200276337-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2020-09-03 | — | — | US | disclosed |
| EP-3687980-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | Institut National de la Sante et de la Recherche Medicale (INSERM) (FR) | 2020-08-05 | — | — | EP | disclosed |
| WO-2019063634-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2019-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11583596-B2 | Radiolabeled Darapladib and analogs thereof and their use as imaging compounds | PLA2G4B, PLA2G1B, PLA2G12B | ALDH1A1 1616/4885CYP3A4 4428/4885CYP2C9 4581/4885 |
| US-20230302162-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | PLA2G4B, PLA2G1B, PLA2G12B | ALDH1A1 1616/4885CYP3A4 4428/4885CYP2C9 4581/4885 |
| US-20200276337-A1 | RADIOLABELED DARAPLADIB AND ANALOGS THEREOF AND THEIR USE AS IMAGING COMPOUNDS | PLA2G4B, PLA2G1B, PLA2G12B | ALDH1A1 1616/4885CYP3A4 4428/4885CYP2C9 4581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.