Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2083481 | 0.81 | SRC (0.68) | SRCRAB9AMAPTNPC1MEN1 | |
| SCHEMBL28899222 | 0.81 | SRC (1.00) | SRCRAB9AMAPTNPC1MEN1 | |
| SCHEMBL2086090 | 0.76 | SRC (0.60) | SRCMAPTNPC1MEN1MAPK1 | |
| SCHEMBL4718633 | 0.75 | SMN1; SMN2 (0.40) | SRCRAB9AMAPTNPC1MEN1 | |
| SCHEMBL5466629 | 0.74 | CES2 (0.52) | RAB9AMAPTNPC1MEN1MAPK1 | |
| SCHEMBL5013789 | 0.74 | MLYCD (0.40) | SRCRAB9AMAPTNPC1MEN1 | |
| SCHEMBL22874628 | 0.73 | CES2 (0.56) | RAB9AMAPTNPC1MEN1KMT2A | |
| SCHEMBL3169534 | 0.73 | RAB9A (0.44) | SRCRAB9AMAPTNPC1MEN1 | |
| SCHEMBL11299913 | 0.73 | CES1 (0.46) | RAB9AMAPTNPC1MEN1MAPK1 | |
| SCHEMBL9692051 | 0.73 | SMN1; SMN2 (0.41) | SRCRAB9AMAPTNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885717-B1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | MAX DELBRUECK CENTRUM (DE) | 2011-08-17 | — | — | EP | disclosed |
| US-7868185-B2 | Shp-2 inhibitors and pharmaceutical compositions comprising them | MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) | 2011-01-11 | — | — | US | disclosed |
| US-20080194563-A1 | Shp-2 Inhibitors, Pharmaceutical Compositons Comprising Them and Their Use For Treating Phosphatase-Mediated Diseases | MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (DE) | 2008-08-14 | — | — | US | disclosed |
| EP-1885717-A1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006128909-A1 | SHP-2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE FOR TREATING PHOSPHATASE-MEDIATED DISEASES | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194563-A1 | Shp-2 Inhibitors, Pharmaceutical Compositons Comprising Them and Their Use For Treating Phosphatase-Mediated Diseases | PTPN2, PTPRJ, PTPRS | SRC 71/4885RAB9A 2407/4885MAPT 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.