Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20862381 | 0.84 | PLAT (0.44) | NR1I2ALOX5PPARGPPARAKDM4E | |
| SCHEMBL20921369 | 0.81 | TSHR (0.42) | NR1I2KDM4EALDH1A1TP53CYP3A4 | |
| SCHEMBL24485981 | 0.81 | NR1I2 (0.39) | NR1I2KDM4EALDH1A1POLBPLAT | |
| SCHEMBL24781216 | 0.81 | NR1I2 (0.39) | NR1I2KDM4EALDH1A1POLBPLAT | |
| SCHEMBL18891619 | 0.81 | CYP1A2 (0.40) | NR1I2KDM4EALDH1A1MAPTHTT | |
| SCHEMBL6055091 | 0.80 | ALDH1A1 (0.43) | PTGESALOX5PPARGPPARAKDM4E | |
| SCHEMBL598619 | 0.79 | NR1I2 (0.49) | NR1I2KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL28343866 | 0.79 | NR1I2 (0.49) | NR1I2KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL14120590 | 0.79 | CA2 (0.42) | PTGESALOX5PPARGPPARAKDM4E | |
| SCHEMBL13593566 | 0.78 | PNMT (0.38) | NR1I2KDM4EALDH1A1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3461824-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Biogen MA Inc. (US) | 2019-04-03 | — | — | EP | disclosed |