Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 2/20 | 0.62 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11393390 | 0.87 | TPMT (0.49) | TPMTERN1MEN1KMT2ATDP1 | |
| SCHEMBL13557412 | 0.82 | TPMT (0.66) | TPMTMEN1KMT2ASNCATDP1 | |
| SCHEMBL2088203 | 0.82 | TUBB4A (0.49) | TPMTABCB1ABCC1MEN1KMT2A | |
| SCHEMBL4069709 | 0.81 | TPMT (0.64) | TPMTABCB1ABCC1MEN1KMT2A | |
| SCHEMBL31447509 | 0.81 | TPMT (0.64) | TPMTERN1MEN1KMT2ATDP1 | |
| SCHEMBL8680266 | 0.81 | TPMT (0.64) | TPMTERN1MEN1KMT2ATDP1 | |
| Methoxymethane SCHEMBL27733049 | 0.81 | ERN1 (0.56) | ERN1ABCB1ABCC1MEN1KMT2A | |
| SCHEMBL20523543 | 0.79 | TPMT (0.43) | TPMTERN1MEN1KMT2ATDP1 | |
| SCHEMBL2306549 | 0.79 | TPMT (0.43) | TPMTERN1ABCB1ABCC1MEN1 | |
| SCHEMBL5207454 | 0.79 | TPMT (0.43) | TPMTERN1ABCB1ABCC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103230389-A | Novel nitrocatechol derivatives having selectin ligand activity | REVOTAR BIOPHARMACEUTICALS AG | 2013-08-07 | — | — | CN | disclosed |
| CN-101374508-B | Novel nitrocatechol derivatives having selectin ligand activity | REVOTAR BIOPHARMACEUTICALS AG | 2013-04-24 | — | — | CN | disclosed |
| US-20110053939-A1 | NOVEL AROMATIC NITRO COMPOUNDS | REVOTAR BIOPHARMACEUTICALS AG (DE) | 2011-03-03 | — | — | US | disclosed |
| US-7851501-B2 | Aromatic nitrocatechol compounds and their use for modulating processes mediated by cell adhesion molecules | REVOTAR BIOPHARMACEUTICALS AG (DE) | 2010-12-14 | — | — | US | disclosed |
| US-20090105280-A1 | Novel Aromatic Nitro Compounds | REVOTAR BIOPHARMACEUTICALS AG (DE) | 2009-04-23 | — | — | US | disclosed |
| CN-101374508-A | Novel nitrocatechol derivatives having selectin ligand activity | REVOTAR BIOPHARMACEUTICALS AG (DE) | 2009-02-25 | — | — | CN | disclosed |
| EP-1937238-A1 | NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY | Revotar Biopharmaceuticals AG (DE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039114-A1 | NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY | REVOTAR BIOPHARMACEUTICALS AG (DE) | 2007-04-12 | — | — | WO | disclosed |
| EP-1764095-A1 | Novel nitrocatechol derivatives having selectin ligand activity | Revotar Biopharmaceuticals AG (DE) | 2007-03-21 | — | — | EP | disclosed |
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105280-A1 | Novel Aromatic Nitro Compounds | SELP, SELE, SELL | TPMT 751/4885ERN1 2685/4885ABCB1 12/4885 |
| US-20110053939-A1 | NOVEL AROMATIC NITRO COMPOUNDS | SELP, SELE, SELL | TPMT 751/4885ERN1 2685/4885ABCB1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.