Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13557412 | 0.87 | TPMT (0.66) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL9657631 | 0.87 | MAPT (0.56) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL15199259 | 0.84 | GPR35 (0.56) | MAPTMAPK1KDM4EMEN1KMT2A | |
| SCHEMBL31447509 | 0.82 | TPMT (0.64) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL8680266 | 0.82 | TPMT (0.64) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL11141699 | 0.82 | MAPT (0.49) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL2402093 | 0.81 | GPR35 (0.61) | MAPTMAPK1KDM4EMEN1KMT2A | |
| SCHEMBL2086471 | 0.81 | TPMT (0.62) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL5038570 | 0.80 | MAPT (0.54) | TPMTMAPTMAPK1KDM4EMEN1 | |
| SCHEMBL15872024 | 0.80 | MAPK1 (0.50) | TPMTMAPTMAPK1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211900-B2 | DHFR enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2012-07-03 | — | — | US | disclosed |
| US-20090118311-A1 | DHFR Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-05-07 | — | — | US | disclosed |
| EP-2013189-A1 | DHFR ENZYME INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007132146-A1 | DHFR ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007129020-A1 | PYRIMIDINE DERIVATIVES USEFUL AS DHFR INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118311-A1 | DHFR Enzyme Inhibitors | DHFR, MTHFD1, ALDH7A1 | TPMT 248/4885MAPT 4527/4885MAPK1 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.