Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512228 | 1.00 | RAPGEF4 (0.39) | RAPGEF4TRPM8SLC6A2EPAS1GPR139 | |
| SCHEMBL4185015 | 0.85 | CES2 (0.37) | RAPGEF4MDM2 | |
| SCHEMBL4547915 | 0.84 | TRPM8 (0.38) | RAPGEF4TRPM8SLC6A2EPAS1GPR139 | |
| SCHEMBL16099813 | 0.83 | TSHR (0.47) | RAPGEF4GABRA1GABRB1TSHRAPP | |
| SCHEMBL17418027 | 0.83 | TSHR (0.47) | RAPGEF4GABRA1GABRB1TSHRAPP | |
| SCHEMBL16099814 | 0.83 | TSHR (0.47) | RAPGEF4GABRA1GABRB1TSHRAPP | |
| SCHEMBL21868533 | 0.80 | TRPM8 (0.37) | RAPGEF4TRPM8EPAS1GPR139GABRA1 | |
| SCHEMBL8738082 | 0.80 | TRPM8 (0.37) | RAPGEF4TRPM8EPAS1GPR139GABRA1 | |
| SCHEMBL17069210 | 0.80 | TRPM8 (0.37) | RAPGEF4TRPM8EPAS1GPR139GABRA1 | |
| SCHEMBL1835863 | 0.80 | EPAS1 (0.43) | RAPGEF4TRPM8SLC6A2EPAS1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111212830-B | N- (substituted sulfonyl) benzamide derivative and preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-111212830-A | N- (substituted sulfonyl) benzamide derivative and preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2020-05-29 | — | — | CN | disclosed |
| WO-2019062848-A1 | N-(SUBSTITUTED SULFONYL)BENZAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 浙江海正药业股份有限公司 | 2019-04-04 | — | — | WO | disclosed |