Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.59 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.59 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.59 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.59 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CCR4 | P51679 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16210903 | 0.84 | POLB (0.65) | PKMPOLBPSEN1PSEN2APH1B | |
| SCHEMBL31107095 | 0.82 | CASP3 (0.66) | HCRTR1HCRTR2TSHRMCOLN3LMNA | |
| SCHEMBL10870111 | 0.80 | MCOLN3 (0.54) | PKMHCRTR1HCRTR2TSHRMCOLN3 | |
| SCHEMBL3456984 | 0.80 | MCOLN3 (0.56) | PKMHCRTR1HCRTR2TSHRMCOLN3 | |
| SCHEMBL19000604 | 0.79 | PSEN1 (0.70) | PKMPOLBPSEN1PSEN2APH1B | |
| SCHEMBL9893151 | 0.79 | PSEN1 (0.70) | PKMPOLBPSEN1PSEN2APH1B | |
| SCHEMBL12169293 | 0.79 | PSEN1 (0.70) | PKMPOLBPSEN1PSEN2APH1B | |
| SCHEMBL8318861 | 0.79 | HCRTR1 (0.67) | HCRTR1HCRTR2TSHRMCOLN3LMNA | |
| SCHEMBL14132587 | 0.78 | PSEN1 (0.69) | PKMPOLBPSEN1PSEN2APH1B | |
| SCHEMBL9893067 | 0.78 | PSEN1 (0.92) | PKMPOLBPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190099453-A1 | MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE | HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190099453-A1 | MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE | PYGL, HNF4A, ATF1 | PKM 248/4885POLB 3588/4885PSEN1 4744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.