Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | IL17A | Q16552 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870201 | 0.86 | RORC (0.46) | RORCNPC1RAB9ASCN9ACNR2 | |
| SCHEMBL20870218 | 0.86 | RORC (0.46) | RORCNPC1RAB9AIL17ASCN9A | |
| SCHEMBL22297975 | 0.85 | RORC (0.54) | RORCIL17ASCN9ABRD4 | |
| SCHEMBL20870215 | 0.85 | RORC (0.45) | RORCSCN9ACNR2CNR1ACACB | |
| SCHEMBL28715124 | 0.84 | BRD4 (0.45) | RORCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20870488 | 0.83 | RORC (0.44) | RORCSCN9AXDHBRD4 | |
| SCHEMBL22262327 | 0.82 | ALDH1A1 (0.52) | SCN9ACNR2CNR1BRD4 | |
| SCHEMBL20529251 | 0.81 | RORC (0.51) | RORCIL17ASCN9A | |
| SCHEMBL20870210 | 0.81 | RORC (0.51) | RORCSCN9A | |
| SCHEMBL28715152 | 0.81 | BRD4 (0.43) | RORCPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063015-A1 | SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS RORγ INHIBITOR | 正大天晴药业集团股份有限公司 | 2019-04-04 | — | — | WO | disclosed |