Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261421 | 0.88 | ALDH1A1 (0.57) | ALDH1A1LMNATDP1KDM4EMAPT | |
| SCHEMBL7798626 | 0.84 | PDE4B (0.55) | ALDH1A1LMNATDP1MAPTSMN1; SMN2 | |
| SCHEMBL2085735 | 0.82 | LMNA (0.63) | ALDH1A1LMNATDP1POLBMAPT | |
| SCHEMBL12431276 | 0.80 | LMNA (0.57) | ALDH1A1LMNATDP1POLBMAPT | |
| SCHEMBL14538748 | 0.78 | LMNA (0.42) | ALDH1A1LMNATDP1POLBKDM4E | |
| SCHEMBL12513785 | 0.77 | MET (0.53) | ALDH1A1LMNATDP1KDM4EMAPT | |
| SCHEMBL5054313 | 0.77 | MET (0.66) | ALDH1A1LMNATDP1POLBMAPT | |
| SCHEMBL27743824 | 0.77 | POLB (0.46) | ALDH1A1LMNAPOLBKDM4EMAPT | |
| SCHEMBL260681 | 0.76 | LMNA (0.63) | ALDH1A1LMNATDP1POLBMAPT | |
| SCHEMBL4482894 | 0.76 | MET (0.64) | ALDH1A1LMNATDP1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963295-B1 | 3, 6-DIHYDRO-2-OXO-6H-(1,3,4)THIADIAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| EP-1951697-B1 | SUBSTITUTED 5-PHENYL-3,6-DIHYDRO-2-OXO-6H-[1,3,4]THIADIAZINES | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| US-7902186-B2 | Substituted 5-phenyl-3,6-dihydro-2-oxo-6H-1,3,4-thiadiazines | MERCK PATENT GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| US-7902186-B2 | Substituted 5-phenyl-3,6-dihydro-2-oxo-6H-1,3,4-thiadiazines | MERCK PATENT GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| US-7534785-B2 | e.g.1-{3-[5-(4-chlorophenyl)-2-oxo-6H-1,3,4-thiadiazin-3-ylmethyl]phenyl}-3-(1-methylpyrrolidin-3-ylmethyl)urea; inhibitors of tyrosine kinases, in particular Met kinase; antitumor, antiinflammatory agent | MERCK PATENT GESELLSCHAFT (DE) | 2009-05-19 | — | — | US | disclosed |
| US-7534785-B2 | e.g.1-{3-[5-(4-chlorophenyl)-2-oxo-6H-1,3,4-thiadiazin-3-ylmethyl]phenyl}-3-(1-methylpyrrolidin-3-ylmethyl)urea; inhibitors of tyrosine kinases, in particular Met kinase; antitumor, antiinflammatory agent | MERCK PATENT GESELLSCHAFT (DE) | 2009-05-19 | — | — | US | disclosed |
| US-20080318936-A1 | Substituted 5-Phenyl-3,6-Dihydro-2-Oxo-6H-1,3,4-Thiadiazines | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318936-A1 | Substituted 5-Phenyl-3,6-Dihydro-2-Oxo-6H-1,3,4-Thiadiazines | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-25 | — | — | US | disclosed |
| US-20080306052-A1 | 3, 6-Dihydro-2-Oxo-6H-1,3,4,-Thiadiazine Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-11 | — | — | US | disclosed |
| US-20080306052-A1 | 3, 6-Dihydro-2-Oxo-6H-1,3,4,-Thiadiazine Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-11 | — | — | US | disclosed |
| EP-1963295-A1 | 3, 6-DIHYDRO-2-OXO-6H-(1,3,4)THIADIAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| EP-1951697-A1 | SUBSTITUTED 5-PHENYL-3,6-DIHYDRO-2-OXO-6H-[1,3,4]THIADIAZINES | Merck Patent GmbH (DE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007057092-A1 | SUBSTITUTED 5-PHENYL-3,6-DIHYDRO-2-OXO-6H-[1,3,4]THIADIAZINES | MERCK PATENT GMBH (DE) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007057093-A1 | 3, 6-DIHYDRO-2-OXO-6H-(1,3,4)THIADIAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318936-A1 | Substituted 5-Phenyl-3,6-Dihydro-2-Oxo-6H-1,3,4-Thiadiazines | ABL1, RET, ERBB2 | ALDH1A1 994/4885LMNA 4357/4885TDP1 2680/4885 |
| US-20080306052-A1 | 3, 6-Dihydro-2-Oxo-6H-1,3,4,-Thiadiazine Derivatives | MET, ABL1, RET | ALDH1A1 509/4885LMNA 4597/4885TDP1 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.