Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19473769 | 0.87 | NSD2 (0.52) | KCNJ1KCNH2USP30MEN1KMT2A | |
| SCHEMBL19639844 | 0.85 | KCNJ1 (0.45) | KCNJ1KCNH2PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL19457714 | 0.83 | KCNJ1 (0.49) | KCNJ1KCNH2HPGDSNSD2LRRK2 | |
| SCHEMBL19457902 | 0.83 | HPGDS (0.42) | KCNJ1KCNH2HPGDSKDM4EMEN1 | |
| SCHEMBL19457858 | 0.82 | KCNJ1 (0.48) | KCNJ1KCNH2USP30MEN1KMT2A | |
| SCHEMBL19457848 | 0.77 | KCNJ1 (0.53) | KCNJ1KCNH2USP30MAPTNSD2 | |
| SCHEMBL19473757 | 0.76 | USP30 (0.46) | KCNJ1KCNH2USP30MEN1KMT2A | |
| SCHEMBL19457708 | 0.75 | USP30 (0.45) | KCNJ1KCNH2USP30MEN1KMT2A | |
| SCHEMBL20985108 | 0.74 | KCNJ1 (0.40) | KCNJ1KCNH2PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL22890304 | 0.74 | HPGD (0.43) | KDM4ELRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11059810-B2 | Pharmaceutically acceptable salt as renal outer medullary potassium channel inhibitor | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-07-13 | — | — | US | disclosed |
| US-20200123135-A1 | PHARMACEUTICALLY ACCEPTABLE SALT AS RENAL OUTER MEDULLARY POTASSIUM CHANNEL INHIBITOR | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-04-23 | — | — | US | disclosed |
| EP-3466945-A1 | PHARMACEUTICALLY ACCEPTABLE SALT AS RENAL OUTER MEDULLARY POTASSIUM CHANNEL INHIBITOR | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059810-B2 | Pharmaceutically acceptable salt as renal outer medullary potassium channel inhibitor | KCNK10, CASK, KCNN2 | KCNJ1 6/4885KCNH2 20/4885PRKAA2 1329/4885 |
| US-20200123135-A1 | PHARMACEUTICALLY ACCEPTABLE SALT AS RENAL OUTER MEDULLARY POTASSIUM CHANNEL INHIBITOR | KCNK10, CASK, KCNN2 | KCNJ1 6/4885KCNH2 20/4885PRKAA2 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.