Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952763 | 0.81 | GRM5 (0.50) | GRM5POLBMAPTTDP1ALPG | |
| SCHEMBL6815167 | 0.81 | GRM5 (0.50) | GRM5POLBMAPTTP53TDP1 | |
| SCHEMBL30753710 | 0.77 | ALDH1A1 (0.50) | GRM5POLBMAPTTDP1ALPG | |
| SCHEMBL28364062 | 0.77 | TDP1 (0.45) | GRM5POLBMAPTTDP1ALPG | |
| SCHEMBL5177798 | 0.77 | ACHE (0.41) | GRM5POLBMAPTTP53L3MBTL1 | |
| SCHEMBL711648 | 0.75 | GRM5 (0.47) | GRM5POLBMAPTTDP1ALPG | |
| SCHEMBL29993511 | 0.75 | GRM5 (0.47) | GRM5POLBMAPTTDP1ALPG | |
| SCHEMBL11841971 | 0.75 | TDP1 (0.44) | GRM5POLBMAPTTDP1ALPG | |
| SCHEMBL10959400 | 0.75 | CA12 (0.53) | POLBMAPTTP53L3MBTL1PYCR1 | |
| SCHEMBL726899 | 0.74 | ALDH1A1 (0.52) | GRM5MAPTTP53L3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563056-B | Triazoles for modulating intracellular calcium homeostasis | 巴斯克大学 | 2022-08-16 | — | — | CN | disclosed |
| US-11377427-B2 | Triazoles for regulating intracellular calcium homeostasis | UNIVERSIDAD DEL PAIS VASCO (ES) | 2022-07-05 | — | — | US | disclosed |
| EP-3466933-B1 | TRIAZOLES FOR REGULATING INTRACELLULAR CALCIUM HOMEOSTASIS | UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2020-12-02 | — | — | EP | disclosed |
| US-20200317625-A1 | TRIAZOLES FOR REGULATING INTRACELLULAR CALCIUM HOMEOSTASIS | UNIVERSIDAD DEL PAIS VASCO (ES) | 2020-10-08 | — | — | US | disclosed |
| EP-3466933-A1 | TRIAZOLES FOR REGULATING INTRACELLULAR CALCIUM HOMEOSTASIS | Universidad del Pais Vasco (ES) | 2019-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11377427-B2 | Triazoles for regulating intracellular calcium homeostasis | RYR1, ATP2A3, RYR2 | GRM5 786/4885POLB 4843/4885MAPT 1079/4885 |
| US-20200317625-A1 | TRIAZOLES FOR REGULATING INTRACELLULAR CALCIUM HOMEOSTASIS | RYR1, ATP2A3, RYR2 | GRM5 786/4885POLB 4843/4885MAPT 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.