Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 4/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20874229 | 0.97 | TLR7 (0.39) | TLR7GLO1LTA4HPTGS1GSTK1 | |
| Bromide SCHEMBL20874215 | 0.96 | GLO1 (0.41) | TLR7GLO1LTA4HPTGS1GSTK1 | |
| Bromide SCHEMBL20874377 | 0.94 | GLO1 (0.44) | TLR7GLO1LTA4HPTGS1GSTK1 | |
| Bromide SCHEMBL20874346 | 0.94 | GLO1 (0.42) | TLR7GLO1PTGS1GSTK1CYP3A4 | |
| Bromide SCHEMBL20874330 | 0.93 | TLR7 (0.42) | TLR7GLO1LTA4HPTGS1GSTK1 | |
| Bromide SCHEMBL20874203 | 0.92 | GLO1 (0.44) | TLR7GLO1LTA4HCYP3A4CYP2D6 | |
| Bromide SCHEMBL20874193 | 0.92 | GLO1 (0.42) | TLR7GLO1PTGS1GSTK1 | |
| Bromide SCHEMBL20874235 | 0.90 | GLO1 (0.46) | TLR7GLO1LTA4HPTGS1GSTK1 | |
| Bromide SCHEMBL20874207 | 0.90 | GLO1 (0.45) | TLR7GLO1PTGS1GSTK1CYP3A4 | |
| Bromide SCHEMBL20874255 | 0.90 | GLO1 (0.45) | GLO1PTGS1GSTK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468563-B1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | UNIV OREGON STATE (US) | 2023-09-13 | — | — | EP | disclosed |
| US-20190106456-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | OREGON STATE UNIVERSITY (US) | 2019-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106456-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | GSR, TXN2, GLS | TLR7 3908/4885GLO1 106/4885LTA4H 2297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.