Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20874364 | 0.91 | ALDH1A1 (0.44) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874320 | 0.91 | ALDH1A1 (0.44) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874172 | 0.91 | ALDH1A1 (0.44) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874181 | 0.91 | ALDH1A1 (0.44) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874178 | 0.90 | ALDH1A1 (0.46) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874396 | 0.89 | CHRNA7 (0.47) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874314 | 0.88 | CHRNA7 (0.48) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Bromide SCHEMBL20874269 | 0.88 | CHRNA7 (0.48) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL23883175 | 0.78 | ALDH1A1 (0.47) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 | |
| SCHEMBL112783 | 0.77 | ALDH1A1 (0.53) | CYP1A2CYP2D6ALDH1A1TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282817-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | OREGON STATE UNIVERSITY (US) | 2025-09-11 | — | — | US | disclosed |
| EP-3468563-B1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | UNIV OREGON STATE (US) | 2023-09-13 | — | — | EP | disclosed |
| US-20190106456-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | OREGON STATE UNIVERSITY (US) | 2019-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106456-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | GSR, TXN2, GLS | CHRM2 4317/4885CHRM4 4446/4885CHRM1 4422/4885 |
| US-20250282817-A1 | COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME | GSR, TXN2, GLS | CHRM2 4317/4885CHRM4 4446/4885CHRM1 4422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.