Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29474321 | 0.78 | ACLY (0.41) | PPARAPPARGLMNAHPGDACLY | |
| SCHEMBL20887339 | 0.78 | ACLY (0.41) | PPARAPPARGLMNAHPGDACLY | |
| SCHEMBL20876254 | 0.77 | TYR (0.47) | PPARAPPARGLMNAHPGDACLY | |
| SCHEMBL20876261 | 0.73 | TSHR (0.47) | LMNAHPGDACLYTSHRALDH1A1 | |
| SCHEMBL20876262 | 0.70 | CYP1A2 (0.45) | LMNAHPGDACLYTSHRKDM4E | |
| SCHEMBL24592969 | 0.70 | KDM4E (0.50) | PPARALMNAHPGDALDH1A1KDM4E | |
| SCHEMBL5206673 | 0.69 | HIF1A (0.51) | LMNATSHRKDM4ERAB9ABRD4 | |
| SCHEMBL20876266 | 0.69 | KDM4E (0.49) | LMNAHPGDACLYALDH1A1KDM4E | |
| SCHEMBL1428309 | 0.69 | CA1 (0.56) | HPGDTSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL22407167 | 0.67 | BRD4 (0.42) | ACLYBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3692026-A1 | BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019068783-A1 | BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-04-11 | — | — | WO | disclosed |