Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590268 | 0.75 | GAA (0.49) | LMNAGAAKDM4ECXCR2PLK1 | |
| SCHEMBL9117544 | 0.72 | HIF1A (0.46) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL9206189 | 0.72 | HIF1A (0.46) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL5954191 | 0.69 | GAA (0.57) | TSHRLMNAGAAKDM4EPLK1 | |
| Phenylephrine SCHEMBL5958774 | 0.69 | HIF1A (0.97) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| SCHEMBL20876255 | 0.69 | PPARA (0.43) | TSHRNFKB1RAB9ALMNAGAA | |
| SCHEMBL9081796 | 0.69 | GAA (0.45) | LMNAGAAKDM4ECXCR2PLK1 | |
| Phenylephrine SCHEMBL4712 | 0.69 | HIF1A (1.00) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| Phenylephrine SCHEMBL4711 | 0.69 | HIF1A (1.00) | HIF1AADRB2ADRB1HTR1AADRA2A | |
| Phenylephrine SCHEMBL895602 | 0.69 | HIF1A (1.00) | HIF1AADRB2ADRB1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-B1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LTD (GB) | 2007-09-05 | — | — | EP | disclosed |