Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7035796 | 0.83 | LMNA (0.56) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| SCHEMBL7035797 | 0.83 | LMNA (0.56) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| SCHEMBL20876261 | 0.75 | TSHR (0.47) | HSD17B10PTPN1RAB9ANPC1POLB | |
| SCHEMBL7706013 | 0.74 | HSD17B10 (0.52) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| SCHEMBL31317684 | 0.73 | PTPN1 (0.49) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| SCHEMBL31014147 | 0.73 | PTPN1 (0.56) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| SCHEMBL31014140 | 0.73 | PTPN1 (0.56) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| SCHEMBL9729072 | 0.73 | TNFRSF1A (0.59) | CYP1A2CYP2C19HSD17B10POLBLMNA | |
| (Z)-1,2-Diphenylethene SCHEMBL1604067 | 0.73 | TSHR (0.76) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A | |
| (Z)-1,2-Diphenylethene SCHEMBL1604066 | 0.73 | TSHR (0.76) | CYP1A2CYP2C19HSD17B10PTPN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3692026-A1 | BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019068783-A1 | BENZOFURAN DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2019-04-11 | — | — | WO | disclosed |