SCHEMBL20876280

SCHEMBL20876280

C[CH]C1(c2ccc(Cl)c(Cl)c2)CC1

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 16/20 0.45
SLC6A3 Q01959 16/20 0.45
SLC6A2 P23975 12/20 0.45
KCNH2 Q12809 4/20 0.42
CYP2D6 P10635 1/20 0.41
OPRM1 P35372 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20876286 0.77 SLC6A4 (0.40) SLC6A4SLC6A3SLC6A2OPRM1
SCHEMBL15043671 0.77 SLC6A4 (0.50) SLC6A4SLC6A3SLC6A2KCNH2CYP2D6
SCHEMBL19767368 0.74 SLC6A4 (0.56) SLC6A4SLC6A3SLC6A2
SCHEMBL19772413 0.74 SLC6A4 (0.56) SLC6A4SLC6A3SLC6A2
SCHEMBL19772416 0.74 SLC6A4 (0.56) SLC6A4SLC6A3SLC6A2
SCHEMBL625336 0.73 SLC6A4 (0.50) SLC6A4SLC6A3SLC6A2KCNH2
SCHEMBL15873672 0.73 SLC6A4 (0.50) SLC6A4SLC6A3SLC6A2KCNH2CYP2D6
SCHEMBL15863260 0.73 SLC6A4 (0.50) SLC6A4SLC6A3SLC6A2KCNH2CYP2D6
SCHEMBL14625431 0.72 SLC6A4 (0.50) SLC6A4SLC6A3SLC6A2KCNH2
SCHEMBL3516295 0.72 SLC6A4 (0.51) SLC6A4SLC6A3SLC6A2KCNH2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200267977-A1 MICROBIOCIDAL PICOLINAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-08-27 US disclosed
EP-3692019-A1 MICROBIOCIDAL PICOLINAMIDE DERIVATIVES Syngenta Participations AG (CH) 2020-08-12 EP disclosed
CN-111183133-A Microbicidal picolinamide derivatives 先正达参股股份有限公司 2020-05-19 CN disclosed
WO-2019068812-A1 MICROBIOCIDAL PICOLINAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-04-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200267977-A1 MICROBIOCIDAL PICOLINAMIDE DERIVATIVES PRF1, CASP1, FPR1 SLC6A4 3476/4885SLC6A3 3866/4885SLC6A2 3920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.