Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587130 | 0.85 | KDM4E (0.48) | SOS1KDM4EMEN1KMT2AGRIN1 | |
| SCHEMBL27717372 | 0.82 | SOS1 (0.47) | SOS1KDM4EGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL14126826 | 0.80 | KDM4E (0.71) | KDM4EL3MBTL1 | |
| SCHEMBL3643057 | 0.79 | SOS1 (0.77) | SOS1KDM4EMEN1KMT2AHRH1 | |
| SCHEMBL1807864 | 0.79 | DRD2 (0.53) | KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL31270102 | 0.76 | KDM4E (0.66) | KDM4EL3MBTL1 | |
| SCHEMBL468954 | 0.76 | KDM4E (0.43) | SOS1KDM4EMEN1KMT2AGAA | |
| SCHEMBL9594773 | 0.76 | ROCK1 (0.41) | — | |
| Trifluoroacetic Acid SCHEMBL5034045 | 0.75 | SOS1 (0.56) | SOS1KDM4EGRIN2BHRH4LMNA | |
| SCHEMBL13559371 | 0.75 | KDM4E (0.42) | SOS1KDM4EMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104086633-B | Short fatty acid tail polymyxin derivatives and application thereof | 北方抗生素有限公司 | 2018-02-09 | — | — | CN | disclosed |
| EP-3078672-A1 | POLYMYXIN DERIVATIVES AND USES THEREOF | Northern Antibiotics Oy (FI) | 2016-10-12 | — | — | EP | disclosed |
| EP-2057185-B1 | POLYMYXIN DERIVATIVES AND USES THEREOF | NORTHERN ANTIBIOTICS OY (FI) | 2016-05-11 | — | — | EP | disclosed |
| US-8163773-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-04-24 | — | — | US | disclosed |
| CN-101970461-A | Short-chain fatty acid tail polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY | 2011-02-09 | — | — | CN | disclosed |
| US-20090233920-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-09-17 | — | — | US | disclosed |
| CN-101501063-A | Polymyxin derivatives and uses thereof | NORTHERN ANTIBIOTICS OY (FI) | 2009-08-05 | — | — | CN | disclosed |
| CN-101223140-A | Piperidine derivatives useful in the diagnostic and therapeutic treatment of diseases depending on renin activity | NOVARTIS AG (CH) | 2008-07-16 | — | — | CN | disclosed |
| EP-1907359-A2 | 3,5-SUBSTITUTED PIPERIDINE DERIVATIVES EFFECTIVE ON RENIN-RELATED DISORDERS | Novartis AG (CH) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007006534-A2 | PIPERIDINE DERIVATIVES USEFUL IN THE DIAGNOSTIC AND THERAPEUTIC TREATMENT OF DISEASES DEPENDING ON RENIN ACTIVITY | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233920-A1 | ORGANIC COMPOUNDS | REN, ACE, AGTR1 | SOS1 4669/4885KDM4E 1597/4885MEN1 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.