Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20879157 | 0.82 | SMN1; SMN2 (0.36) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL14691330 | 0.82 | MAPT (0.42) | MEP1BMAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL20879153 | 0.77 | MAPT (0.40) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL20879183 | 0.74 | ALDH1A1 (0.46) | MAPTKDM4ERAB9AALDH1A1GAA | |
| SCHEMBL14692699 | 0.64 | KDM4E (0.42) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL14691590 | 0.64 | SMN1; SMN2 (0.40) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL1457038 | 0.63 | SMN1; SMN2 (0.50) | MAPTKDM4ESMN1; SMN2ALDH1A1GAA | |
| SCHEMBL15770785 | 0.63 | TDP1 (0.42) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL4277272 | 0.60 | PTPN1 (0.43) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL13603906 | 0.59 | RAB9A (0.48) | MAPTKDM4ESMN1; SMN2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070087-B1 | INTERMEDIATES FOR THE SYNTHESIS OF CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-04-10 | — | — | EP | disclosed |