Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | TK1 | P04183 | 2/20 | 0.33 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17533853 | 0.91 | LMNA (0.41) | LMNASMN1; SMN2MAPTESR1TSHR | |
| SCHEMBL25400298 | 0.84 | LMNA (0.44) | LMNASMN1; SMN2MAPTESR1TSHR | |
| SCHEMBL25573323 | 0.83 | TDP1 (0.36) | LMNASMN1; SMN2MAPTP2RY6 | |
| SCHEMBL20879426 | 0.83 | TDP1 (0.36) | LMNASMN1; SMN2MAPTP2RY6 | |
| SCHEMBL15075492 | 0.81 | ALDH1A1 (0.39) | SMN1; SMN2TK1P2RY6 | |
| SCHEMBL15074350 | 0.79 | LMNA (0.40) | LMNASMN1; SMN2MAPTESR1TSHR | |
| SCHEMBL7208634 | 0.79 | LMNA (0.38) | LMNASMN1; SMN2MAPTESR1TSHR | |
| SCHEMBL25399418 | 0.79 | LMNA (0.40) | LMNASMN1; SMN2MAPTESR1TSHR | |
| SCHEMBL30670559 | 0.78 | LMNA (0.45) | LMNASMN1; SMN2MAPTESR1TSHR | |
| SCHEMBL26268262 | 0.74 | LMNA (0.49) | LMNASMN1; SMN2MAPTESR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466959-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen BioPharma, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |