Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.37 |
| ▸ | FOS | P01100 | 2/20 | 0.37 |
| ▸ | JUN | P05412 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085911 | 0.85 | MAPT (0.44) | ALDH1A1CHRNA7CYP1A2CYP2C9KDM4E | |
| SCHEMBL2087890 | 0.85 | OPRK1 (0.43) | ALDH1A1CYP1A2CYP2C9KDM4ECYP3A4 | |
| SCHEMBL15638267 | 0.80 | CHRNA7 (0.51) | ALDH1A1CHRNA7CYP1A2CYP2C9KDM4E | |
| SCHEMBL15636310 | 0.79 | CHRNA7 (0.50) | ALDH1A1CHRNA7CYP1A2CYP2C9CYP2D6 | |
| SCHEMBL2086982 | 0.78 | MAPT (0.50) | ALDH1A1CYP1A2CYP2C9KDM4ECYP3A4 | |
| SCHEMBL2087895 | 0.78 | HTT (0.57) | ALDH1A1CYP1A2KDM4ECYP3A4MAPK1 | |
| SCHEMBL15635743 | 0.75 | LMNA (0.53) | ALDH1A1KDM4EMAPK1HTTTSHR | |
| SCHEMBL4847270 | 0.74 | GAA (0.53) | ALDH1A1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL9591482 | 0.74 | KDM4E (0.46) | ALDH1A1CHRNA7CYP1A2CYP2C9KDM4E | |
| SCHEMBL2087996 | 0.73 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C9KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897612-B2 | Substituted 1,8-naphthyridinecarboxamides for use as prolyl hydroxylase inhibitors | GlaxoSmithKline, LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090082357-A1 | Prolyl Hydroxylase Inhibitors | GLAXOSMITHKLINE LLC | 2009-03-26 | — | — | US | disclosed |
| US-20070213335-A1 | Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082357-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | ALDH1A1 319/4885CHRNA7 4869/4885CYP1A2 183/4885 |
| US-20070213335-A1 | Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | ALDH1A1 319/4885CHRNA7 4869/4885CYP1A2 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.