Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 4/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20889904 | 0.83 | KDM4E (0.34) | KDM4ETSHRACHEHSP90AA1HSP90AB1 | |
| SCHEMBL16477887 | 0.82 | RXRA (0.37) | KDM4ESMN1; SMN2RXRAGRIN1GRIN2B | |
| SCHEMBL11994370 | 0.80 | CYP1A2 (0.46) | KDM4ETSHRRXRAGRIN1GRIN2B | |
| SCHEMBL20909886 | 0.77 | UHRF1 (0.43) | KDM4EMAPTTDP1SMN1; SMN2LIN28A | |
| SCHEMBL20889902 | 0.77 | NOS3 (0.50) | KDM4ETSHRACHEMAPTTDP1 | |
| SCHEMBL13533992 | 0.77 | KDM4E (0.50) | KDM4ETSHRMAPTRXRAGRIN1 | |
| SCHEMBL3184879 | 0.75 | MAPT (0.36) | KDM4ETSHRACHEMAPTTDP1 | |
| SCHEMBL8265623 | 0.75 | ALDH1A1 (0.46) | KDM4EMAPTTDP1HRH3CCR4 | |
| SCHEMBL3507581 | 0.74 | TLR9 (0.38) | KDM4ETSHRSMN1; SMN2RXRAGRIN1 | |
| SCHEMBL21705891 | 0.74 | RXRA (0.35) | RXRAGRIN1GRIN2BALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190106427-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2019-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106427-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | WEE1, WEE2, NME1 | KDM4E 795/4885TSHR 4456/4885ACHE 4746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.