Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20898711 | 0.79 | HSD11B1 (0.42) | — | |
| SCHEMBL23523646 | 0.79 | HSD11B1 (0.42) | — | |
| SCHEMBL23523671 | 0.77 | — | — | |
| SCHEMBL8435167 | 0.72 | GBA2 (0.43) | LMNAPOLBSMN1; SMN2GBA2ECE1 | |
| SCHEMBL22346683 | 0.69 | GBA2 (0.43) | LMNAPOLBSMN1; SMN2GBA2ECE1 | |
| SCHEMBL29639440 | 0.68 | GBA2 (0.50) | LMNAPOLBSMN1; SMN2GBA2ECE1 | |
| SCHEMBL20241634 | 0.66 | GBA2 (0.42) | LMNAPOLBSMN1; SMN2GBA2ECE1 | |
| SCHEMBL30986484 | 0.65 | LMNA (0.41) | LMNAPOLBSMN1; SMN2GBA2IDH1 | |
| SCHEMBL7788793 | 0.64 | GBA2 (0.51) | LMNAPOLBSMN1; SMN2GBA2ECE1 | |
| SCHEMBL26922978 | 0.64 | SMN1; SMN2 (0.43) | LMNAPOLBSMN1; SMN2GBA2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694330-A1 | INDAZOLYL-SPIRO[2.2]PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2020-08-19 | — | — | EP | disclosed |
| WO-2019074809-A1 | INDAZOLYL-SPIRO[2.2]PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2019-04-18 | — | — | WO | disclosed |