Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 13/20 | 0.52 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | UNG | P13051 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563388 | 1.00 | NPC1 (0.58) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL8006745 | 1.00 | NPC1 (0.58) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL2200281 | 1.00 | NPC1 (0.58) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL5948125 | 1.00 | NPC1 (0.58) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL8957600 | 1.00 | NPC1 (0.58) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL7525722 | 1.00 | NPC1 (0.58) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL2089557 | 0.98 | NPC1 (0.59) | NPC1RAB9ANR5A1TP53TSHR | |
| SCHEMBL7533701 | 0.95 | NPC1 (0.54) | NPC1RAB9ANR5A1TSHRFAAH | |
| SCHEMBL9101286 | 0.88 | MAPT (0.49) | NPC1RAB9ATSHRFAAH | |
| SCHEMBL7654166 | 0.83 | PLA2G2A (0.53) | NPC1RAB9ANR5A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-8163753-B2 | 2-(4-(4-(4-chlorophenyl)oxazol-2-yl)phenoxymethyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole; bactericide; excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | OTSUKA PHAMACEUTICAL CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| EP-0457153-B1 | Method for processing a silver halide photographic material | FUJI PHOTO FILM CO LTD (JP) | 2002-09-18 | — | — | EP | disclosed |
| US-5278037-A | Dye particles with anionic polymer hydrophilic layer | FUJI PHOTO FILM CO., LTD. (JP) | 1994-01-11 | — | — | US | disclosed |
| US-5273866-A | Dispersion of microcrystals of compounds having an acidic nucleus and at least one double bond | FUJI PHOTO FILM CO., LTD. (JP) | 1993-12-28 | — | — | US | disclosed |
| US-5232825-A | Scratch resistant, high speed processability; image quality | FUJI PHOTO FILM CO., LTD. (JP) | 1993-08-03 | — | — | US | disclosed |
| US-5098818-A | Multilayer photographic films | FUJI PHOTO FILM CO., LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| US-5079134-A | X-ray film with improved sharpness, reduced crossover, dye which absorbs in sensitive region of silver halide emulsion | FUJI PHOTO FILM CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0457153-A1 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |
| EP-0456163-A2 | Silver halide photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1991-11-13 | — | — | EP | disclosed |
| EP-0423742-A2 | Silver halide color reversal photographic photosensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-04-24 | — | — | EP | disclosed |
| EP-0423693-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-04-24 | — | — | EP | disclosed |
| EP-0337490-A2 | Silver halide light-sensitive photographic material | Fuji Photo Film Co., Ltd. (JP) | 1989-10-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | NPC1 2404/4885RAB9A 2824/4885NR5A1 222/4885 |
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | NR2C2, NR0B2, NR4A2 | NPC1 3130/4885RAB9A 3153/4885NR5A1 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.