Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22307825 | 0.86 | FAAH (0.38) | FAAHCYP2D6BDKRB2CYP3A4NAAA | |
| SCHEMBL27972329 | 0.84 | FAAH (0.37) | FAAHCYP2D6LMNABDKRB2CYP3A4 | |
| SCHEMBL29058174 | 0.79 | GRIN2D (0.44) | LMNAPRSS1PRSS2PRSS3KCNH2 | |
| SCHEMBL21770640 | 0.79 | GRIN2D (0.44) | LMNAPRSS1PRSS2PRSS3KCNH2 | |
| SCHEMBL19732279 | 0.79 | GRIN2D (0.44) | LMNAPRSS1PRSS2PRSS3KCNH2 | |
| SCHEMBL28041066 | 0.78 | CSNK1E (0.37) | FAAHCSNK1E | |
| SCHEMBL27648727 | 0.78 | KCNH2 (0.50) | FAAHCYP2D6LMNACYP3A4NAAA | |
| SCHEMBL9513948 | 0.78 | KCNH2 (0.50) | FAAHCYP2D6LMNACYP3A4NAAA | |
| SCHEMBL22308364 | 0.78 | KCNH2 (0.50) | FAAHCYP2D6LMNACYP3A4NAAA | |
| SCHEMBL18783298 | 0.78 | KCNH2 (0.50) | FAAHCYP2D6LMNACYP3A4NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10259775-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10259775-B2 | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders | AIFM2, GPX1, GPX4 | FAAH 1332/4885CYP2D6 4182/4885LMNA 1599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.