SCHEMBL20904455

SCHEMBL20904455

Fc1ccc(-n2c3ccccc3c3ccc(N(c4ccccc4)c4ccc5c(c4)c4ccccc4n5-c4ccccc4)cc32)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.46
ATM Q13315 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
JAK2 O60674 1/20 0.41
JAK3 P52333 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.39
MAT2A P31153 2/20 0.35
CYP1A2 P05177 1/20 0.34
METAP2 P50579 1/20 0.34
REN P00797 2/20 0.34
USP14 P54578 1/20 0.32
TP53 P04637 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
MAPK8 P45983 1/20 0.32
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CENPE Q02224 1/20 0.32
KDR P35968 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20904342 1.00 KDM4E (0.46) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904251 0.99 KDM4E (0.47) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904403 0.99 KDM4E (0.47) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904457 0.99 KDM4E (0.44) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904454 0.97 ATM (0.49) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904345 0.96 ATM (0.42) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904343 0.95 ATM (0.46) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904456 0.95 ATM (0.46) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL20904436 0.95 ATM (0.47) KDM4EATML3MBTL1JAK2JAK3
SCHEMBL12927985 0.95 KDM4E (0.47) KDM4EATML3MBTL1JAK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10937967-B2 Amine-based compound and organic light-emitting device including the amine-based compound SAMSUNG DISPLAY CO., LTD. (KR) 2021-03-02 US disclosed
US-20190115543-A1 AMINE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE AMINE-BASED COMPOUND SAMSUNG DISPLAY CO., LTD. (KR) 2019-04-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10937967-B2 Amine-based compound and organic light-emitting device including the amine-based compound AOC2, AOC1, SAT1 KDM4E 495/4885ATM 792/4885L3MBTL1 665/4885
US-20190115543-A1 AMINE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE AMINE-BASED COMPOUND AOC2, AOC1, SAT1 KDM4E 495/4885ATM 792/4885L3MBTL1 665/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.