Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839087 | 0.85 | TDP1 (0.47) | PSIP1TDP1SMN1; SMN2HSD11B1ALDH1A1 | |
| SCHEMBL3421644 | 0.83 | HTR6 (0.45) | PSIP1TDP1PKMSMN1; SMN2SIRT2 | |
| SCHEMBL27943041 | 0.81 | TDP1 (0.44) | PSIP1TDP1PKMSMN1; SMN2TP53 | |
| SCHEMBL1286162 | 0.81 | TDP1 (0.44) | PSIP1TDP1PKMSMN1; SMN2TP53 | |
| SCHEMBL28376769 | 0.81 | TDP1 (0.44) | PSIP1TDP1PKMSMN1; SMN2TP53 | |
| SCHEMBL4618662 | 0.78 | PSIP1 (0.59) | PSIP1TDP1SMN1; SMN2TP53HSD11B1 | |
| SCHEMBL23239464 | 0.77 | PSIP1 (0.46) | PSIP1TDP1GAAPKMSMN1; SMN2 | |
| SCHEMBL21186462 | 0.77 | PSIP1 (0.46) | PSIP1TDP1GAAPKMSMN1; SMN2 | |
| SCHEMBL27348634 | 0.77 | MEN1 (0.38) | PSIP1TDP1GAAALDH1A1GLA | |
| SCHEMBL29207385 | 0.76 | HTR6 (0.39) | PSIP1TDP1PKMSMN1; SMN2SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019073431-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST AND ITS INTERMEDIATE | Piramal Enterprises Limited (IN) | 2019-04-18 | — | — | WO | disclosed |