Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 5/20 | 0.47 |
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | BACE1 | P56817 | 4/20 | 0.47 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24200353 | 0.86 | CHRM2 (0.52) | POLBACHEMEN1KMT2A | |
| SCHEMBL17138501 | 0.86 | CHRM2 (0.52) | POLBACHEMEN1KMT2A | |
| SCHEMBL6581110 | 0.82 | PER2 (0.51) | SIGMAR1 | |
| SCHEMBL7805639 | 0.82 | PER2 (0.51) | SIGMAR1 | |
| SCHEMBL6579768 | 0.82 | PER2 (0.51) | SIGMAR1 | |
| SCHEMBL18133746 | 0.78 | BCHE (0.44) | POLBBCHETDP1SIGMAR1 | |
| SCHEMBL7846535 | 0.78 | OPRK1 (0.43) | SIGMAR1 | |
| SCHEMBL26100782 | 0.77 | HRH3 (0.52) | ACHETRPV6 | |
| SCHEMBL20909098 | 0.75 | BCHE (0.59) | ACHEBCHEBACE1TRPV6TDP1 | |
| SCHEMBL20908728 | 0.75 | HRH3 (0.46) | ACHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694836-B1 | PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF | ZAI LAB SHANGHAI CO LTD (CN) | 2022-06-15 | — | — | EP | disclosed |
| WO-2019072237-A1 | PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF | ZAI LAB (SHANGHAI) CO., LTD. (CN) | 2019-04-18 | — | — | WO | disclosed |