Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanfacine SCHEMBL35094 | 0.89 | KMT2A (0.54) | P2RX7KMT2AADRA2ACYP3A4LMNA | |
| Guanfacine SCHEMBL1173133 | 0.88 | ADRA2A (0.53) | P2RX7KMT2AADRA2ACYP3A4LMNA | |
| Guanfacine SCHEMBL41681 | 0.88 | ADRA2A (0.53) | P2RX7KMT2AADRA2ACYP3A4LMNA | |
| Guanfacine SCHEMBL438188 | 0.86 | AKR1B1 (0.53) | KMT2AADRA2ACYP3A4LMNAMEN1 | |
| SCHEMBL10998822 | 0.84 | P2RX7 (0.46) | P2RX7KMT2ALMNAAKR1B1NPC1 | |
| Guanfacine SCHEMBL5539292 | 0.84 | KMT2A (0.49) | KMT2AADRA2ACYP3A4LMNAMEN1 | |
| Guanfacine SCHEMBL439673 | 0.83 | KMT2A (0.43) | P2RX7KMT2AADRA2ACYP3A4LMNA | |
| Guanfacine SCHEMBL790727 | 0.83 | AKR1B1 (0.46) | P2RX7KMT2AADRA2ACYP3A4LMNA | |
| Guanfacine SCHEMBL437682 | 0.82 | MAPT (0.43) | P2RX7KMT2AADRA2ACYP3A4LMNA | |
| SCHEMBL31514234 | 0.82 | ALDH1A1 (0.43) | P2RX7KMT2ALMNAMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019072997-A1 | TRANSDERMAL THERAPEUTIC SYSTEM FOR THE TRANSDERMAL ADMINISTRATION OF GUANFACINE COMPRISING A SILICONE POLYMER | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2019-04-18 | — | — | WO | disclosed |