Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14273272 | 0.85 | MKNK1 (0.47) | PARP10ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL2144444 | 0.79 | NPC1 (0.37) | ALDH1A1HPGDHSD17B10CA9MKNK1 | |
| SCHEMBL8221967 | 0.79 | PARP10 (0.46) | PARP10ROS1CDK5ACVR1LRRK2 | |
| SCHEMBL29657028 | 0.79 | PARP1 (0.42) | PARP10PARP1CA1CA2CA7 | |
| SCHEMBL17141573 | 0.79 | TGM2 (0.46) | PARP10PARP1ALDH1A1MAPTKDM4E | |
| SCHEMBL14992279 | 0.79 | PPOX (0.50) | PARP10CDK5ACVR1LRRK2PARP1 | |
| SCHEMBL14991900 | 0.79 | PARP1 (0.42) | PARP10PARP1CA1CA2CA7 | |
| SCHEMBL30029469 | 0.79 | TGM2 (0.46) | PARP10PARP1ALDH1A1MAPTKDM4E | |
| SCHEMBL28159452 | 0.78 | MKNK1 (0.39) | ALDH1A1MAPTHPGDHSD17B10MKNK1 | |
| SCHEMBL20884018 | 0.77 | ALDH1A1 (0.44) | PARP1ALDH1A1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019074979-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GIRAFPHARMA, LLC (US) | 2019-04-18 | — | — | WO | disclosed |