Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13345546 | 0.84 | MEN1 (0.52) | MEN1KMT2AALDH1A1NPSR1DRD2 | |
| SCHEMBL24192767 | 0.83 | KMT2A (0.51) | MEN1KMT2AALDH1A1NPSR1DRD2 | |
| SCHEMBL20889996 | 0.83 | XIAP (0.43) | MEN1KMT2ADRD2RAB9AGFER | |
| SCHEMBL24478514 | 0.83 | HTR5A (0.46) | MEN1KMT2AALDH1A1NPSR1DRD2 | |
| SCHEMBL22549193 | 0.80 | CHRM2 (0.53) | MEN1KMT2AALDH1A1NPSR1DRD2 | |
| SCHEMBL22543662 | 0.79 | DRD2 (0.39) | MEN1KMT2ADRD2RAB9AGFER | |
| SCHEMBL24478527 | 0.77 | KIF11 (0.34) | MEN1KMT2ADRD2KDM4EXIAP | |
| SCHEMBL24478250 | 0.77 | DRD2 (0.45) | MEN1KMT2AALDH1A1DRD2KDM4E | |
| SCHEMBL15756197 | 0.76 | KMT2A (0.55) | MEN1KMT2AALDH1A1DRD2KDM4E | |
| SCHEMBL521473 | 0.76 | DRD2 (0.57) | ALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210380-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| WO-2019074979-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | GIRAFPHARMA, LLC (US) | 2019-04-18 | — | — | WO | disclosed |