Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10109854 | 0.78 | PTPN2 (0.49) | PTPN2KDM4EL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL422589 | 0.78 | POLB (0.57) | PTPN2KDM4EL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL22607895 | 0.75 | USP2 (0.47) | CYP4F2CYP4A11PTPN2USP2KDM4E | |
| SCHEMBL19737212 | 0.75 | MAPK14 (0.41) | CYP4F2CYP4A11KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL20926005 | 0.75 | CYP4F2 (0.38) | CYP4F2CYP4A11PTPN2KDM4EL3MBTL1 | |
| SCHEMBL23135913 | 0.75 | MAPK14 (0.39) | CYP4F2CYP4A11KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL28939258 | 0.73 | ALDH1A1 (0.43) | CYP4F2CYP4A11KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2653067 | 0.73 | HDAC3 (0.51) | CYP4F2CYP4A11KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL7836036 | 0.73 | CYP4A11 (0.44) | CYP4F2CYP4A11KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL1529648 | 0.72 | USP2 (0.51) | PTPN2USP2KDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583525-A | Pyrazoloazepine AKT inhibitor | 南京正大天晴制药有限公司 | 2023-08-11 | — | — | CN | disclosed |
| EP-3725791-B1 | SALT SERVING AS AKT INHIBITOR AND CRYSTAL THEREOF | HARBIN ZHENBAO PHARMACEUTICAL CO LTD (CN) | 2023-03-15 | — | — | EP | disclosed |
| WO-2022121788-A1 | PYRAZOLOAZEPINE AKT INHIBITOR | 南京正大天晴制药有限公司 | 2022-06-16 | — | — | WO | disclosed |
| EP-3725791-A1 | SALT SERVING AS AKT INHIBITOR AND CRYSTAL THEREOF | Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) | 2020-10-21 | — | — | EP | disclosed |
| US-10654868-B2 | Dihydropyrazole azepine compound serving as Akt inhibitor | Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) | 2020-05-19 | — | — | US | disclosed |
| US-20190233434-A1 | DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR | Harbin Zhenbao Pharmaceutical Co., Ltd. (CN) | 2019-08-01 | — | — | US | disclosed |
| EP-3473628-A1 | DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR | Medshine Discovery Inc. (CN) | 2019-04-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654868-B2 | Dihydropyrazole azepine compound serving as Akt inhibitor | AKT3, AKT2, AKT1 | CYP4F2 3483/4885CYP4A11 3180/4885PTPN2 568/4885 |
| US-20190233434-A1 | DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR | AKT3, AKT2, AKT1 | CYP4F2 3483/4885CYP4A11 3180/4885PTPN2 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.