SCHEMBL422589

SCHEMBL422589

CCOC(=O)c1cc(Br)c(Br)s1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.57
PKM P14618 1/20 0.57
MAPT P10636 3/20 0.55
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
GSK3B P49841 2/20 0.53
LMNA P02545 1/20 0.50
PTPN2 P17706 2/20 0.49
CSNK2A2 P19784 1/20 0.46
CSNK2B P67870 1/20 0.46
CSNK2A1 P68400 1/20 0.46
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
ALDH1A1 P00352 2/20 0.44
HPGD P15428 2/20 0.44
KDM4E B2RXH2 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6739730 0.86 PTPN2 (0.46) POLBPKMMAPTMEN1KMT2A
SCHEMBL10109854 0.86 PTPN2 (0.49) POLBPKMMAPTMEN1KMT2A
SCHEMBL7042355 0.83 GSK3B (0.50) POLBPKMMAPTMEN1KMT2A
SCHEMBL1529974 0.79 GSK3B (0.53) POLBPKMMAPTMEN1KMT2A
SCHEMBL20912901 0.78 CYP4F2 (0.46) POLBPKMMAPTMEN1KMT2A
SCHEMBL3878737 0.78 USP10 (0.56) POLBPKMMAPTKMT2ALMNA
SCHEMBL2241077 0.77 TSHR (0.52) MAPTMEN1KMT2APTPN2HDAC3
SCHEMBL20481990 0.77 PTPN2 (0.47) POLBPKMMAPTMEN1KMT2A
SCHEMBL6812309 0.76 PTPN2 (0.49) POLBPKMMAPTMEN1KMT2A
SCHEMBL6286251 0.76 TDP1 (0.51) POLBPKMMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240170735-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION 2024-05-23 US claimed
EP-4315472-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION (US) 2024-02-07 EP claimed
WO-2022212634-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION (US) 2022-10-06 WO claimed
US-20240170735-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION 2024-05-23 US disclosed
EP-4315472-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION (US) 2024-02-07 EP disclosed
CN-117157792-A Flame retardant for battery electrolyte 雅宝公司 2023-12-01 CN disclosed
WO-2022212634-A1 FLAME RETARDANTS FOR BATTERY ELECTROLYTES ALBEMARLE CORPORATION (US) 2022-10-06 WO disclosed
WO-2019169479-A1 DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL DENOVAMED INC. (CA) 2019-09-12 WO disclosed
US-9975910-B2 Hetero-fused cyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2018-05-22 US disclosed
US-20160168176-A1 HETERO-FUSED CYCLIC COMPOUND Eisai R&D Management Co., Lt.d (JP) 2016-06-16 US disclosed
EP-3026054-A1 HETERO-CONDENSED RING COMPOUND Eisai R&D Management Co., Ltd. (JP) 2016-06-01 EP disclosed
US-8546438-B2 Substituted (thiophenyl-carbonyl)imidazolidinones, and use thereof BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2013-10-01 US disclosed
EP-2376482-B1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO KG (DE) 2013-03-06 EP disclosed
WO-2012116452-A1 ANTIMICROBIAL/ADJUVANT COMPOUNDS AND METHODS DENOVAMED INC. (CA) 2012-09-07 WO disclosed
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 US disclosed
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 US disclosed
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2012-01-26 US disclosed
WO-2010075962-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF AICURIS GMBH & CO. KG (DE) 2010-07-08 WO disclosed
US-20100076028-A1 Design and Synthesis of Novel Antimicrobials WU FAN 2010-03-25 US disclosed
WO-2006092059-A1 DESIGN AND SYNTHESIS OF NOVEL ANTIMICROBIALS WU FAN (CA) 2006-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100076028-A1 Design and Synthesis of Novel Antimicrobials MLX, LPXN, TPX2 POLB 1277/4885PKM 2814/4885MAPT 4883/4885
US-20160168176-A1 HETERO-FUSED CYCLIC COMPOUND NR3C2, NR1H4, NR1I3 POLB 2899/4885PKM 3913/4885MAPT 4653/4885
US-20120022123-A1 SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF TPMT, MAVS, EIF2AK2 POLB 1390/4885PKM 726/4885MAPT 2657/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.