Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594722 | 1.00 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1GABRG2GABRB3GABRA5 | |
| SCHEMBL13844048 | 0.82 | NR1H2 (0.38) | GABRG2GABRB3GABRA5NR1H2GABRA1 | |
| SCHEMBL19249737 | 0.80 | TRPV3 (0.39) | GABRG2GABRB3GABRA5NR1H2NR1H3 | |
| SCHEMBL22537577 | 0.80 | CCR9 (0.40) | HSP90AA1HSP90AB1GABRG2GABRB3GABRA5 | |
| SCHEMBL15091451 | 0.78 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1LMNAKMT2A | |
| SCHEMBL4389624 | 0.78 | AKR1C3 (0.49) | NR1H2LMNAKMT2ANR1H3AKR1C3 | |
| SCHEMBL17522859 | 0.77 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1GABRG2GABRB3GABRA5 | |
| SCHEMBL16205502 | 0.77 | GABRG2 (0.41) | HSP90AA1HSP90AB1GABRG2GABRB3GABRA5 | |
| SCHEMBL32673595 | 0.77 | CDK2 (0.44) | HSP90AA1HSP90AB1GABRG2GABRB3GABRA5 | |
| SCHEMBL12685164 | 0.77 | POLB (0.41) | GABRG2GABRB3GABRA5NR1H2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717734-B2 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof | PHARMAXIS LTD. (AU) | 2020-07-21 | — | — | US | disclosed |
| US-20190119269-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | PHARMAXIS LTD. (AU) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10717734-B2 | Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof | IDO1, IDO2, INMT | HSP90AA1 2830/4885HSP90AB1 2383/4885GABRG2 4340/4885 |
| US-20190119269-A1 | INDOLE AND AZAINDOLE HALOALLYLAMINE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF | IDO1, IDO2, INMT | HSP90AA1 2830/4885HSP90AB1 2383/4885GABRG2 4340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.