Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20898678 | 0.78 | IDO1 (0.51) | RAB9ANPC1ALDH1A1SMN1; SMN2IDO1 | |
| SCHEMBL9936063 | 0.75 | ALDH1A1 (0.44) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL20919703 | 0.75 | RAB9A (0.41) | RAB9ANPC1ALDH1A1TSHRFPR2 | |
| SCHEMBL20919720 | 0.74 | KDR (0.39) | FFAR2IDO1 | |
| SCHEMBL9990405 | 0.74 | OPRL1 (0.47) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL20898986 | 0.73 | IDO1 (0.53) | RAB9ANPC1ALDH1A1SMN1; SMN2IDO1 | |
| SCHEMBL20919672 | 0.73 | RAB9A (0.40) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL9990471 | 0.73 | KDM4E (0.39) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL20972276 | 0.72 | IDO1 (0.57) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL9989391 | 0.71 | OPRL1 (0.47) | MEN1KMT2ARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |