Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 3/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20919737 | 0.88 | FFAR2 (0.43) | KDRWNT3AIDO1HSD11B1FFAR2 | |
| SCHEMBL20919796 | 0.81 | WNT3A (0.36) | KDRWNT3AANO1IDO1BRAF | |
| SCHEMBL20938161 | 0.78 | KDR (0.40) | KDRANO1PIP5K1CPIK3CAPI4KA | |
| SCHEMBL20919702 | 0.78 | FFAR2 (0.44) | KDRIDO1FFAR2 | |
| SCHEMBL20919701 | 0.76 | GRM5 (0.39) | KDRWNT3AIDO1HSD11B1FFAR2 | |
| SCHEMBL20919686 | 0.74 | MEN1 (0.44) | IDO1FFAR2 | |
| SCHEMBL20919682 | 0.70 | HDAC1 (0.44) | KDRWNT3AIDO1 | |
| SCHEMBL18135104 | 0.70 | GAA (0.56) | KDRBRAF | |
| SCHEMBL20919680 | 0.69 | ALDH1A1 (0.60) | KDRWNT3AIDO1 | |
| SCHEMBL20919712 | 0.69 | KDR (0.41) | KDRIDO1BRAFHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | claimed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | claimed |
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |