SCHEMBL20923973

SCHEMBL20923973

N#Cc1ccc(SNc2cc(-c3ccc(C4CC4)cn3)cc(C(F)(F)F)c2)cc1

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 15/20 0.55
MAOA P21397 4/20 0.37
MAOB P27338 6/20 0.37
DGAT1 O75907 2/20 0.36
P2RY14 Q15391 1/20 0.35
HSD11B1 P28845 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20924271 0.78 KDM1A (0.53) KDM1AMAOAMAOBDGAT1
SCHEMBL20924184 0.77 KDM1A (0.68) KDM1AMAOAMAOBDGAT1
SCHEMBL20924225 0.75 KDM1A (0.51) KDM1AMAOAMAOB
SCHEMBL20924093 0.75 KDM1A (0.50) KDM1AMAOAMAOBDGAT1
SCHEMBL20924205 0.73 KDM1A (0.67) KDM1AMAOAMAOBHSD11B1
SCHEMBL20923927 0.71 KDM1A (0.71) KDM1AMAOAMAOBDGAT1
SCHEMBL530541 0.71 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL15136585 0.71 KDM1A (1.00) KDM1AMAOAMAOB
SCHEMBL15136620 0.71 KDM1A (1.00) KDM1AMAOAMAOB
Hydrochloric Acid SCHEMBL527391 0.70 KDM1A (0.98) KDM1AMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2598480-B1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2019-04-24 EP disclosed