SCHEMBL20924009

SCHEMBL20924009

Oc1cc(Cl)cc(-c2ccc(C3CC3)cn2)c1

nearest known ligand 0.69

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 16/20 0.69
MAOB P27338 3/20 0.54
GRM5 P41594 2/20 0.42
MAOA P21397 1/20 0.42
DEGS1 O15121 1/20 0.38
DGAT1 O75907 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20924015 0.89 KDM1A (0.65) KDM1AMAOBGRM5MAOADGAT1
SCHEMBL20924262 0.82 KDM1A (0.69) KDM1AMAOB
SCHEMBL15137192 0.82 KDM1A (1.00) KDM1AMAOBMAOA
SCHEMBL526445 0.82 KDM1A (1.00) KDM1AMAOBMAOA
SCHEMBL526444 0.82 KDM1A (1.00) KDM1AMAOBMAOA
Hydrochloric Acid SCHEMBL527976 0.81 KDM1A (0.97) KDM1AMAOBMAOA
Hydrochloric Acid SCHEMBL527975 0.81 KDM1A (0.97) KDM1AMAOBMAOA
SCHEMBL20923927 0.79 KDM1A (0.71) KDM1AMAOBMAOADGAT1
SCHEMBL20924186 0.79 KDM1A (0.48) KDM1AGRM5MAOA
SCHEMBL20923991 0.79 KDM1A (0.71) KDM1AMAOBGRM5MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2598480-B1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS ORYZON GENOMICS SA (ES) 2019-04-24 EP disclosed