Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | USP7 | Q93009 | 4/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765638 | 0.84 | OPRM1 (0.46) | NOTUMMEN1KMT2AUSP7ESR2 | |
| SCHEMBL29410679 | 0.84 | OPRM1 (0.46) | NOTUMMEN1KMT2AUSP7ESR2 | |
| SCHEMBL20923972 | 0.81 | HSD17B1 (0.63) | NOTUMESR2ESR1FYNKDM1A | |
| SCHEMBL171398 | 0.80 | USP7 (0.42) | USP7 | |
| SCHEMBL31351745 | 0.79 | ESR2 (0.49) | NOTUMMEN1KMT2AIDO1USP7 | |
| SCHEMBL15150077 | 0.77 | KDM1A (0.58) | MEN1NPC1RAB9AKMT2AUSP7 | |
| SCHEMBL20924043 | 0.77 | NOTUM (0.46) | NOTUMMEN1KMT2AIDO1ESR2 | |
| SCHEMBL527152 | 0.77 | KDM1A (0.58) | MEN1NPC1RAB9AKMT2AUSP7 | |
| SCHEMBL528955 | 0.77 | KDM1A (0.58) | MEN1NPC1RAB9AKMT2AUSP7 | |
| SCHEMBL527153 | 0.77 | KDM1A (0.58) | MEN1NPC1RAB9AKMT2AUSP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598480-B1 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS | ORYZON GENOMICS SA (ES) | 2019-04-24 | — | — | EP | disclosed |