Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.51 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.51 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.51 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.51 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.47 |
| ▸ | VEGFA | P15692 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21608370 | 0.93 | TBK1 (0.49) | TBK1PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL28644780 | 0.87 | GHSR (0.57) | TBK1GPR119RET | |
| SCHEMBL31458848 | 0.87 | GHSR (0.57) | TBK1GPR119RET | |
| SCHEMBL30042412 | 0.87 | MEN1 (0.49) | TBK1GPR119MEN1KMT2AATM | |
| SCHEMBL2933302 | 0.87 | MEN1 (0.49) | TBK1GPR119MEN1KMT2AATM | |
| SCHEMBL30520640 | 0.85 | MEN1 (0.50) | TBK1GPR119MEN1KMT2AATM | |
| SCHEMBL12557699 | 0.84 | KMT2A (0.69) | GPR119MEN1KMT2AATMVEGFA | |
| SCHEMBL114519 | 0.84 | VEGFA (0.50) | TBK1GPR119MEN1KMT2AATM | |
| SCHEMBL1997213 | 0.84 | MEN1 (0.49) | TBK1GPR119MEN1KMT2AATM | |
| SCHEMBL30584532 | 0.84 | MEN1 (0.49) | TBK1GPR119MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527292-A | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-113527290-A | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-113527291-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2021-10-22 | — | — | CN | disclosed |
| EP-1963315-B1 | ENZYME INHIBITORS | CANCER REC TECH LTD (GB) | 2014-10-08 | — | — | EP | disclosed |
| US-8088761-B2 | Enzyme inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-01-03 | — | — | US | disclosed |
| US-8088761-B2 | Enzyme inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-01-03 | — | — | US | disclosed |
| US-8088761-B2 | Enzyme inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-01-03 | — | — | US | disclosed |
| US-20090247507-A1 | Enzyme Inhibitors | THE INSTITUTE OF CANCER RESEARCH (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247507-A1 | Enzyme Inhibitors | THE INSTITUTE OF CANCER RESEARCH (GB) | 2009-10-01 | — | — | US | disclosed |
| US-20090247507-A1 | Enzyme Inhibitors | THE INSTITUTE OF CANCER RESEARCH (GB) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247507-A1 | Enzyme Inhibitors | AURKC, AURKB, AURKA | TBK1 1046/4885PRKAA2 2352/4885PRKAB2 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.