Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18029358 | 0.86 | JAK2 (0.45) | JAK2JAK1TYK2JAK3KLK6 | |
| SCHEMBL19872670 | 0.81 | LRRK2 (0.39) | JAK2JAK1TYK2JAK3CSF1R | |
| SCHEMBL18029159 | 0.79 | KIF11 (0.47) | KLK6KIF11EGFRCDK2MEN1 | |
| SCHEMBL21392032 | 0.78 | KLK6 (0.47) | JAK2JAK1TYK2JAK3KLK6 | |
| SCHEMBL21392230 | 0.71 | KIF11 (0.50) | KLK6KIF11EGFRCDK2MEN1 | |
| SCHEMBL31025881 | 0.70 | ALDH1A1 (0.53) | JAK2JAK1TYK2JAK3KIF11 | |
| SCHEMBL20120034 | 0.69 | GRIK1 (0.38) | JAK2JAK1TYK2JAK3KLK6 | |
| SCHEMBL19871236 | 0.67 | PTPRA (0.56) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL18028986 | 0.67 | PTPRA (0.56) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL18029390 | 0.67 | PTGS2 (0.41) | JAK2JAK1TYK2JAK3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550079-B2 | Artificial self-sufficient cytochrome P450s | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190119208-A1 | ARTIFICIAL SELF-SUFFICIENT CYTOCHROME P450S | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550079-B2 | Artificial self-sufficient cytochrome P450s | CYP4F2, CYP2F1, POR | JAK2 4632/4885JAK1 4676/4885TYK2 3966/4885 |
| US-20190119208-A1 | ARTIFICIAL SELF-SUFFICIENT CYTOCHROME P450S | CYP4F2, CYP2F1, POR | JAK2 4632/4885JAK1 4676/4885TYK2 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.