Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 3/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 8/20 | 0.32 |
| ▸ | WNT1 | P04628 | 5/20 | 0.32 |
| ▸ | CLK2 | P49760 | 3/20 | 0.32 |
| ▸ | CLK3 | P49761 | 3/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048883 | 0.87 | NNMT (0.36) | NNMTHCAR3DYRK1AACACBACACA | |
| SCHEMBL24219714 | 0.86 | WNT1 (0.31) | DYRK1AABL1GSK3BWNT1CLK2 | |
| SCHEMBL23740805 | 0.86 | DYRK1A (0.33) | NNMTDYRK1AABL1GSK3BWNT1 | |
| SCHEMBL24219230 | 0.85 | DYRK1A (0.34) | DYRK1AABL1GSK3BWNT1CLK2 | |
| SCHEMBL23048823 | 0.84 | NNMT (0.34) | NNMTHCAR3DYRK1AACACBACACA | |
| SCHEMBL23740995 | 0.83 | MAP4K4 (0.34) | HCAR3DYRK1AABL1GSK3BWNT1 | |
| SCHEMBL24218981 | 0.83 | WNT1 (0.32) | DYRK1AABL1GSK3BWNT1CLK2 | |
| SCHEMBL23740780 | 0.81 | GSK3B (0.53) | DYRK1AABL1GSK3BWNT1 | |
| SCHEMBL24219437 | 0.81 | GSK3B (0.40) | DYRK1AABL1GSK3BWNT1 | |
| SCHEMBL23740828 | 0.81 | GSK3B (0.51) | DYRK1AABL1GSK3BWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943086-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BioSplice Therapeutics, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |
| EP-3448386-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019079626-A1 | 6-(5-MEMBERED HETEROARYL)ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED, LLC (US) | 2019-04-25 | — | — | WO | disclosed |