Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16591602 | 0.86 | HSD17B10 (0.41) | HSD17B10ALDH1A1SMN1; SMN2TSHRITGB3 | |
| SCHEMBL25959561 | 0.84 | HSD17B10 (0.40) | HSD17B10ALDH1A1SMN1; SMN2TSHRITGB3 | |
| SCHEMBL25959855 | 0.84 | HSD17B10 (0.40) | HSD17B10ALDH1A1SMN1; SMN2TSHRITGB3 | |
| SCHEMBL22332274 | 0.84 | HSD17B10 (0.61) | HSD17B10ALDH1A1SMN1; SMN2TSHRITGB3 | |
| SCHEMBL15337884 | 0.77 | HSD17B10 (0.50) | HSD17B10ALDH1A1YAP1TEAD4CYP2C19 | |
| SCHEMBL13627850 | 0.77 | HSD17B10 (0.45) | PTGESHSD17B10ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL25962302 | 0.73 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KMT2ACYP2C9CYP2C19 | |
| SCHEMBL19002780 | 0.72 | NAAA (0.54) | PTGESHSD17B10ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL16591610 | 0.71 | CYP2D6 (0.45) | HSD17B10ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL18997256 | 0.71 | SMN1; SMN2 (0.56) | HSD17B10SMN1; SMN2KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119295-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119295-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | KRAS, HRAS, NRAS | PTGES 2561/4885HSD17B10 3787/4885ALDH1A1 2792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.