Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.54 |
| ▸ | WNT1 | P04628 | 4/20 | 0.52 |
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.41 |
| ▸ | KDM5A | P29375 | 3/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | KDM5C | P41229 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29630836 | 0.87 | DDB1 (0.59) | KDM2BWNT1GSK3BDYRK1ADDB1 | |
| SCHEMBL24462341 | 0.87 | DDB1 (0.59) | KDM2BWNT1GSK3BDYRK1ADDB1 | |
| SCHEMBL20951194 | 0.84 | WNT1 (0.49) | KDM2BWNT1GSK3BDYRK1ADDB1 | |
| SCHEMBL23048583 | 0.77 | WNT1 (0.41) | KDM2BWNT1GSK3BDYRK1AALDH1A1 | |
| SCHEMBL19546938 | 0.74 | WNT1 (0.39) | KDM2BWNT1GSK3BDYRK1A | |
| SCHEMBL25390798 | 0.74 | DDB1 (0.44) | DDB1CRBNKDM4CKDM4EKDM5C | |
| SCHEMBL24473911 | 0.73 | DDB1 (0.62) | WNT1GSK3BDYRK1ADDB1CRBN | |
| SCHEMBL24462087 | 0.73 | HCRTR2 (0.56) | WNT1GSK3BDYRK1ADDB1CRBN | |
| SCHEMBL29551148 | 0.73 | HCRTR2 (0.56) | WNT1GSK3BDYRK1ADDB1CRBN | |
| SCHEMBL23280356 | 0.73 | KDM2B (0.54) | KDM2BWNT1GSK3BDYRK1AJMJD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703748-B2 | Diazanaphthalen-3-yl carboxamides and preparation and use thereof | SAMUMED, LLC (US) | 2020-07-07 | — | — | US | disclosed |
| US-10703748-B2 | Diazanaphthalen-3-yl carboxamides and preparation and use thereof | SAMUMED, LLC (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190127370-A1 | DIAZANAPHTHALEN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | VICKERS-SPLICE CO-INVESTMENT LLC (KY) | 2019-05-02 | — | — | US | disclosed |
| US-20190127370-A1 | DIAZANAPHTHALEN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | VICKERS-SPLICE CO-INVESTMENT LLC (KY) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127370-A1 | DIAZANAPHTHALEN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | DYRK1A, DKK1, WNT1 | KDM2B 2459/4885WNT1 3/4885GSK3B 19/4885 |
| US-10703748-B2 | Diazanaphthalen-3-yl carboxamides and preparation and use thereof | DYRK1A, DKK1, WNT1 | KDM2B 2459/4885WNT1 3/4885GSK3B 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.