Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | WNT1 | P04628 | 2/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KDM6B | O15054 | 2/20 | 0.43 |
| ▸ | KDM5C | P41229 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23062923 | 0.87 | KDM4C (0.49) | KDM2BOPRK1KCNH2KDM4EKDM6B | |
| SCHEMBL17572955 | 0.87 | PRMT5 (0.55) | PRMT5OPRK1KCNH2KDM4EKDM6B | |
| SCHEMBL19473383 | 0.86 | KDM1A (0.45) | KDM2BGSK3BDYRK1AWNT1PRMT5 | |
| SCHEMBL17559414 | 0.85 | PRMT5 (0.46) | GSK3BDYRK1AWNT1PRMT5OPRK1 | |
| SCHEMBL30281322 | 0.84 | LOX (0.49) | OPRK1KCNH2KMT2AKDM4EKDM6B | |
| SCHEMBL17572116 | 0.82 | GPR119 (0.53) | — | |
| SCHEMBL19460867 | 0.82 | GPR119 (0.51) | PRMT5 | |
| SCHEMBL30578274 | 0.82 | KDM2B (0.58) | KDM2BJMJD6KDM4EKDM6BKDM5C | |
| SCHEMBL19473358 | 0.81 | OPRK1 (0.41) | KDM2BGSK3BDYRK1AWNT1PRMT5 | |
| SCHEMBL17572814 | 0.81 | WNT1 (0.48) | KDM2BGSK3BDYRK1AWNT1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |