Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11671492 | 0.84 | LMNA (0.42) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL11672204 | 0.73 | LMNA (0.39) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL16869230 | 0.73 | LMNA (0.39) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL11437472 | 0.73 | SMN1; SMN2 (0.55) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL11671408 | 0.72 | LMNA (0.53) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL11670967 | 0.72 | ESR1 (0.41) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL18935672 | 0.69 | ESR1 (0.43) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL11688587 | 0.69 | ESR1 (0.39) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL11843716 | 0.69 | MPO (0.37) | MAPTLMNASMN1; SMN2HSD17B1RECQL | |
| SCHEMBL14938096 | 0.69 | SMN1; SMN2 (0.44) | MAPTLMNASMN1; SMN2HSD17B1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273241-B2 | Cortistatin analogues and syntheses and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273241-B2 | Cortistatin analogues and syntheses and uses thereof | CDK19, CDK9, CDK1 | MAPT 4345/4885LMNA 1351/4885SMN1; SMN2 3513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.