Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20470550 | 0.87 | RAB9A (0.42) | MAPTRAB9ANPC1L3MBTL1LMNA | |
| SCHEMBL23228767 | 0.83 | PARP10 (0.44) | MAPTMAPK1SLC6A4HTR2AKCNH2 | |
| SCHEMBL21166650 | 0.83 | MAPT (0.57) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL23228801 | 0.81 | RAB9A (0.45) | MAPTRAB9ANPC1LMNAMAPK1 | |
| SCHEMBL24091750 | 0.81 | HSPB1 (0.51) | MAPTL3MBTL1ALDH1A1HSPB1 | |
| SCHEMBL23228792 | 0.80 | ALDH1A1 (0.44) | MAPTLMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL31225194 | 0.79 | RAB9A (0.65) | MAPTRAB9ANPC1L3MBTL1LMNA | |
| SCHEMBL15054858 | 0.79 | RAB9A (0.65) | MAPTRAB9ANPC1L3MBTL1LMNA | |
| SCHEMBL23228809 | 0.79 | SLC6A2 (0.46) | MAPTALDH1A1HPGDSLC6A4 | |
| SCHEMBL21656973 | 0.79 | HDAC1 (0.42) | MAPTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11085918-B2 | Method for identifying modulators of notch signaling | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2021-08-10 | — | — | US | disclosed |
| US-20190219566-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2019-07-18 | — | — | US | disclosed |
| US-10274481-B2 | Method for identifying modulators of notch signaling | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10274481-B2 | Method for identifying modulators of notch signaling | NOTCH3, NOTCH1, NOTCH4 | MAPT 3343/4885RAB9A 3388/4885NPC1 1941/4885 |
| US-20190219566-A1 | METHOD FOR IDENTIFYING MODULATORS OF NOTCH SIGNALING | NOTCH3, NOTCH1, NOTCH4 | MAPT 3343/4885RAB9A 3388/4885NPC1 1941/4885 |
| US-11085918-B2 | Method for identifying modulators of notch signaling | NOTCH3, NOTCH1, NOTCH4 | MAPT 3343/4885RAB9A 3388/4885NPC1 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.