Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 2/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17107860 | 0.90 | PTGES (0.68) | SHBGSMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL27994919 | 0.87 | CSNK2A2 (0.61) | SHBGSMN1; SMN2HPGDMAPTPTGES | |
| SCHEMBL28045620 | 0.85 | PTGES (0.75) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL20953941 | 0.81 | MEN1 (0.51) | SMN1; SMN2HPGDCYP3A4LMNATP53 | |
| SCHEMBL17114049 | 0.81 | CA12 (0.50) | SMN1; SMN2HPGDMAPTCYP3A4TP53 | |
| SCHEMBL17128868 | 0.78 | MAPT (0.46) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL17128890 | 0.77 | CYP1A2 (0.52) | SMN1; SMN2HPGDMAPTCYP3A4TP53 | |
| SCHEMBL17128867 | 0.76 | MAP1LC3B (0.45) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL17114051 | 0.75 | HPGD (0.48) | SMN1; SMN2NPC1HPGDCYP3A4TP53 | |
| SCHEMBL17128888 | 0.74 | MAP1LC3B (0.47) | SMN1; SMN2HPGDMAPTCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122735-B1 | 3-PHENYL-7-HYDROXY-ISOCOUMARINS AS MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) INHIBITORS | THE PROVOST FELLOWS FOUND SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIV (IE) | 2019-05-08 | — | — | EP | disclosed |