Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.49 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20953928 | 0.81 | SHBG (0.59) | HPGDKDM4ECYP3A4ESR1LMNA | |
| SCHEMBL17114051 | 0.80 | HPGD (0.48) | MEN1KMT2AHPGDKDM4ECYP3A4 | |
| SCHEMBL17107860 | 0.79 | PTGES (0.68) | HPGDKDM4ECYP3A4ALOX5PTGES | |
| SCHEMBL17128870 | 0.78 | HSD17B3 (0.42) | MEN1KMT2AHPGDKDM4ECYP3A4 | |
| SCHEMBL17128801 | 0.78 | MEN1 (0.43) | MEN1KMT2AHPGDKDM4ECYP3A4 | |
| SCHEMBL17128804 | 0.78 | MEN1 (0.43) | MEN1KMT2AHPGDKDM4ECYP3A4 | |
| SCHEMBL17128798 | 0.77 | MEN1 (0.42) | MEN1KMT2AHPGDKDM4ECYP3A4 | |
| SCHEMBL17128792 | 0.77 | C1R (0.47) | MEN1KMT2AHPGDESR1LMNA | |
| SCHEMBL17128807 | 0.76 | MEN1 (0.41) | MEN1KMT2AHPGDKDM4ECYP3A4 | |
| SCHEMBL17128793 | 0.75 | HSD17B3 (0.44) | MEN1KMT2AHPGDCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122735-B1 | 3-PHENYL-7-HYDROXY-ISOCOUMARINS AS MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) INHIBITORS | THE PROVOST FELLOWS FOUND SCHOLARS AND THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIV (IE) | 2019-05-08 | — | — | EP | disclosed |