Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176970 | 0.78 | TDP1 (0.56) | CYP1A2MAPK8MAPK9MAPK10CYP3A4 | |
| SCHEMBL6670697 | 0.77 | CYP1A2 (0.60) | CYP1A2LOXL2MAPK9CYP3A4CYP2D6 | |
| SCHEMBL6174947 | 0.77 | PKM (0.54) | CYP1A2LOXL2L3MBTL1ALDH1A1HPGD | |
| SCHEMBL1888048 | 0.77 | PREP (0.44) | CYP1A2CYP3A4HTR2CHTR2BALDH1A1 | |
| SCHEMBL13496176 | 0.75 | CYP4F2 (0.45) | CYP1A2CYP3A4CYP2D6L3MBTL1ALDH1A1 | |
| SCHEMBL5456634 | 0.75 | CYP1A2 (0.67) | CYP1A2LOXL2CYP3A4CYP2D6HIF1A | |
| SCHEMBL18505712 | 0.75 | HDAC4 (0.37) | HIF1AFAAHALDH1A1HPGDHSD17B10 | |
| SCHEMBL25139494 | 0.74 | CYP1A2 (0.57) | CYP1A2LOXL2MAPK9CYP3A4CYP2D6 | |
| SCHEMBL20346367 | 0.74 | NAPRT (0.44) | CYP1A2L3MBTL1 | |
| SCHEMBL3775943 | 0.73 | CYP1A2 (0.60) | CYP1A2LOXL2MAPK9CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3480193-B1 | PYRAZOLE DERIVATIVES AS ALK5 INHIBITORS AND USES THEREOF | HANMI PHARMACEUTICAL CO LTD (KR) | 2024-05-29 | — | — | EP | disclosed |
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2021-03-23 | — | — | US | disclosed |
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2019-06-27 | — | — | US | disclosed |
| EP-3480193-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | Hanmi Pharmaceutical Co., Ltd. (KR) | 2019-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194198-A1 | NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF | ALK, SMAD3, TGFBR1 | CYP1A2 4593/4885LOXL2 927/4885MAPK8 256/4885 |
| US-10954232-B2 | Pyrazole derivative as ALK5 inhibitor and uses thereof | ALK, SMAD3, TGFBR1 | CYP1A2 4586/4885LOXL2 812/4885MAPK8 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.